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A new dimension of 1 H‐NMR spectroscopy in assessment of liver graft dysfunction
Author(s) -
Singh H. K.,
Yachha S. K.,
Saxena Rajan,
Gupta Ashish,
Nagana Gowda G. A.,
Bhandari M.,
Khetrapal C. L.
Publication year - 2003
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.829
Subject(s) - glutamine , urine , urea , urinary system , nuclear magnetic resonance spectroscopy , medicine , concomitant , urea cycle , transplantation , chemistry , excretion , endocrinology , biochemistry , amino acid , organic chemistry , arginine
Abstract High‐resolution 1 H‐NMR spectroscopy of serum and urine samples of an 11‐year‐old male living related orthotopic liver transplant recipient is reported. Serum glutamine increased to abnormal levels along with simultaneous abnormal excretion of urinary glutamine post‐transplantation. High levels of glutamine in both blood and urine and concomitant reduced urea levels in urine were found to be evidence of impairment in urea cycle and compatible with persistently abnormal graft function. Thus glutamine levels in serum and urine, and urea in the urine as observed by 1 H‐NMR spectroscopy highlight their important roles in monitoring liver graft function; increased glutamine levels lead to brain damage, if untreated. Copyright © 2003 John Wiley & Sons, Ltd.