Premium
MR imaging of postischemic neuronal death in the substantia nigra and thalamus following middle cerebral artery occlusion in rats
Author(s) -
Abe O.,
Nakane M.,
Aoki S.,
Hayashi N.,
Masumoto T.,
Kunimatsu A.,
Mori H.,
Tamura A.,
Ohtomo K.
Publication year - 2003
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.823
Subject(s) - substantia nigra , thalamus , medicine , middle cerebral artery , anatomy , midbrain , neuroscience , cardiology , central nervous system , dopamine , psychology , ischemia , radiology , dopaminergic
The goal of this study was to investigate apparent diffusion coefficient (ADC) and T 2 relaxation time ( T 2 ) in the substantia nigra and thalamus after middle cerebral artery occlusion in rats. In the substantia nigra ipsilateral to infarct, ADC was significantly lower and T 2 was significantly higher on the third and fourth days, but they did not change significantly on the first, second, eighth and 15th days. In the ipsilateral thalamus, ADC and T 2 did not change significantly between the first and fourth days, but were significantly lower on the eighth and 15th days. This combination of MR findings suggested that secondary degeneration in the thalamus was different from that in the substantia nigra. Copyright © 2003 John Wiley & Sons, Ltd.