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Diffusion tensor imaging and aging – a review
Author(s) -
Moseley Michael
Publication year - 2002
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.785
Subject(s) - diffusion mri , white matter , fractional anisotropy , contrast (vision) , diffusion imaging , nuclear magnetic resonance , population , diffusion , magnetic resonance imaging , neuroscience , medicine , biology , physics , radiology , optics , environmental health , thermodynamics
Diffusion‐tensor imaging (DTI) non‐invasively provides maps of microscopic structural information of oriented tissue in vivo , which is finding utility in studies of the aging population. In contrast to the white matter maturation process, investigators have observed significant declines in the white matter ordering in normal as well as in abnormal aging. These studies suggest that water proton non‐random, anisotropic diffusion measured by DTI is highly sensitive to otherwise subtle disease processes not normally seen with conventional MRI tissue contrast mechanisms. Copyright © 2002 John Wiley & Sons, Ltd.