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Monitoring acute inflammatory processes in mouse muscle by MR imaging and spectroscopy: a comparison with pathological results
Author(s) -
RuizCabello Jesús,
Regadera Javier,
Santisteban Carmen,
Graña Manuel,
Alejo Rigoberto Pérez de,
Echave Imanol,
Avilés Pablo,
Rodriguez Ignacio,
Santos Inmaculada,
Gargallo Domingo,
Cortijo Manuel
Publication year - 2002
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.761
Subject(s) - magnetic resonance imaging , phosphocreatine , histopathology , nuclear magnetic resonance , pathology , pathological , nuclear magnetic resonance spectroscopy , segmentation , inflammation , medicine , nuclear medicine , radiology , artificial intelligence , computer science , physics , energy metabolism
We have studied an animal model of acute local inflammation in muscle induced by Aspergillus fumigatus by using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). We have compared our data to those found using histopathology and segmentation maps obtained by the mathematical processing of three‐dimensional T 2 ‐weighted MRI data via a neural network. The MRI patterns agreed satisfactorily with the clinical and biological evidence of the phases of acute local infection and its evolution towards chronicity. The MRS results show a statistically significant increase in inorganic phosphate and a significant decrease in phosphocreatine levels in the inflamed region. Image segmentation made with a self‐organizing, neural‐network map yielded a set of ordered representatives that remained constant for all animals during the inflammatory process, allowing a non‐invasive, three‐dimensional identification and quantification of the inflamed infected regions by MRI. Copyright © 2002 John Wiley & Sons, Ltd.