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Monitoring cytotoxic tumour treatment response by diffusion magnetic resonance imaging and proton spectroscopy
Author(s) -
Kauppinen Risto A.
Publication year - 2002
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.742
Subject(s) - cytotoxic t cell , radiation therapy , magnetic resonance imaging , diffusion mri , nuclear magnetic resonance , medicine , chemotherapy , cancer research , pathology , diffusion , nuclear medicine , chemistry , radiology , biochemistry , in vitro , physics , thermodynamics
Exposure of tumours to anti‐cancer drugs, gene or radiation therapy consistently leads to an increase in water diffusion in the cases expressing favourable treatment response. The diffusion change coincides cytotoxic cell eradication and precedes volume reduction in drug or gene therapy‐treated experimental tumours. Interestingly, the recent studies from human brain tumour patients undergoing chemotherapy show similar behaviour of diffusion, suggesting important application for MRI in patient management. In this review observations from diffusion MRI and MRS in the tumours during cytotoxic treatment are summarized and the cellular mechanisms affecting molecular mobility are discussed in the light of tissue microenvironmental and microdynamic changes. Copyright © 2002 John Wiley & Sons, Ltd.