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FAIR exempting separate T 1 measurement (FAIREST): a novel technique for online quantitative perfusion imaging and multi‐contrast fMRI
Author(s) -
Lai Song,
Wang Jiongjiong,
Jahng GeonHo
Publication year - 2001
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.738
Subject(s) - cerebral blood flow , nuclear magnetic resonance , perfusion scanning , contrast (vision) , perfusion , pixel , materials science , nuclear medicine , biomedical engineering , artificial intelligence , computer science , physics , medicine , radiology , cardiology
A new pulse sequence, dubbed FAIR exempting separate T 1 measurement (FAIREST) in which a slice‐selective saturation recovery acquisition is added in addition to the standard FAIR (flow‐sensitive alternating inversion recovery) scheme, was developed for quantitative perfusion imaging and multi‐contrast fMRI. The technique allows for clean separation between and thus simultaneous assessment of BOLD and perfusion effects, whereas quantitative cerebral blood flow (CBF) and tissue T 1 values are monitored online. Online CBF maps were obtained using the FAIREST technique and the measured CBF values were consistent with the off‐line CBF maps obtained from using the FAIR technique in combination with a separate sequence for T 1 measurement. Finger tapping activation studies were carried out to demonstrate the applicability of the FAIREST technique in a typical fMRI setting for multi‐contrast fMRI. The relative CBF and BOLD changes induced by finger‐tapping were 75.1 ± 18.3 and 1.8 ± 0.4%, respectively, and the relative oxygen consumption rate change was 2.5 ± 7.7%. The results from correlation of the T 1 maps with the activation images on a pixel‐by‐pixel basis show that the mean T 1 value of the CBF activation pixels is close to the T 1 of gray matter while the mean T 1 value of the BOLD activation pixels is close to the T 1 range of blood and cerebrospinal fluid. Copyright © 2001 John Wiley & Sons, Ltd.