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Measurement of intravascular Na + during increased CBF using 23 Na NMR with a shift reagent
Author(s) -
Ronen Itamar,
Kim SeongGi
Publication year - 2001
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.736
Subject(s) - sodium , chemistry , hypercapnia , cerebral blood flow , reagent , intravascular volume status , isotopes of sodium , nuclear magnetic resonance , hemodynamics , medicine , acidosis , physics , organic chemistry
Sodium ions are intimately involved with neural activity. Thus, it is highly desirable to devise a way of mapping brain activity via sodium imaging. Sodium ions exist in the extravascular and intravascular spaces. To separate the two components, the shift reagent Tm(DOTP) 5− was intravenously introduced into rats. Intravascular sodium changes in the rat brain were measured during increased blood flow induced by hypercapnia using volume‐localized 23 Na‐NMR. The intravascular sodium changes, equivalent to cerebral blood volume changes, are significant during hypercapnia conditions and correlate well with the increase in arterial pCO 2 . This suggests that the intravascular sodium change is dominant in total 23 Na spectroscopy or imaging of the brain during blood flow increase induced by external perturbation. Copyright © 2001 John Wiley & Sons, Ltd.