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Decoupling of the short‐term hemodynamic response and the blood oxygen concentration
Author(s) -
Janz Clemens,
Schmitt Christina,
Kornmayer Jens,
Speck Oliver,
Hennig Jürgen
Publication year - 2001
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.712
Subject(s) - blood oxygen level dependent , hemodynamics , cerebral blood flow , oxygen , functional magnetic resonance imaging , blood flow , haemodynamic response , oxygenation , magnetic resonance imaging , nuclear magnetic resonance , blood oxygenation , perfusion , neuroscience , chemistry , medicine , psychology , physics , heart rate , blood pressure , organic chemistry , radiology
Neuronal activation leads to an increase in the local cortical perfusion. The exact regulatory mechanisms leading to these changes are still unknown. To elucidate the role of oxygen in the initial hemodynamic regulation, a disactivation paradigm was performed with fMRI. A stimulus was applied following a previous extended activation in order to evoke physiological variations of the local oxygen concentration. The results demonstrate that the initial hemodynamic response time is independent of the local blood oxygen concentration. Copyright © 2001 John Wiley & Sons, Ltd. Abbrevations used: BOLD blood oxygenation level dependentCBF cerebral blood flowCMRO 2 cerebral metabolic rate of oxygenfMRI functional magnetic resonance imagingFOV field‐of‐viewGE‐EPI gradient echo–echo planar imaging