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MR spectroscopy quantitation: a review of frequency domain methods
Author(s) -
Mierisová Šárka,
AlaKorpela Mika
Publication year - 2001
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.697
Subject(s) - computer science , automation , domain (mathematical analysis) , data science , engineering , mathematics , mechanical engineering , mathematical analysis
Abstract There has been a vast increase in applications of magnetic resonance spectroscopy (MRS) in biomedical research during the last few years. This is not surprising since MRS provides both in vivo and in vitro a non‐invasive tool for various biochemical and biomedical studies. There are also expectations that clinical MRS will have an important role as a diagnostic tool. An essential prerequisite for the future success of MRS for applicability in biomedical sciences will be accurate and biochemically relevant data analysis (at as high a level of automation as possible). This review briefly describes principles of the methodology available for advanced quantitative data analysis in the frequency domain. Various biomedical applications are discussed in order to illustrate the practical aspects of the analyses and to show the applicability and power of biochemical prior knowledge‐based lineshape fitting analysis. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used: Asp aspartateCho cholineCr creatineEMCL extra‐myocellular lipidsFID free induction decayFT Fourier transformGABA γ‐aminobutyric acidGlu glutamateGln glutamineGlc glucoseGPC glycerophosphocholineGPE glycerophosphoethanolamineHDL high density lipoproteinIDL intermediate density lipoproteinIMCL intra‐myocellular lipidsLDL low density lipoproteinP i inorganic phosphatemyo ‐Ins myo ‐inositolNAA N ‐acetyl‐aspartateNAAG N ‐acetylaspartylglutamateNTP nucleotide triphosphatesPC phosphocholinePCr phosphocreatinePDE phosphodiestersPE phosphoethanolaminePME phosphomonoestersscyllo ‐Ins scyllo ‐inositolSNR signal‐to‐noise ratioTau taurineTDFD frequency domain fitting using time domain modelsTLS total lineshapeTSP sodium 3‐trimethylsilyl[2,2,3,3‐D 4 ] propionateVLDL very low density lipoprotein.