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Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component
Author(s) -
Huang Hua,
Zheng CunJing,
Wang LiFei,
CheNordin Nazmi,
Wáng Yì Xiáng J.
Publication year - 2021
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4449
Subject(s) - intravoxel incoherent motion , diffusion , nuclear magnetic resonance , nuclear medicine , medicine , magnetic resonance imaging , diffusion mri , physics , radiology , thermodynamics
The aim of this study was to establish reference values for middle‐aged subjects and to investigate the age and gender dependence of liver diffusion MRI parameters. The IVIM type of liver diffusion scan was based on a single‐shot spin‐echo–type echo‐planar sequence using a 1.5 T magnet with 16 b ‐values. Diffusion‐derived vessel density (DDVD)(b0b2) or DDVD(b0b10) was the signal difference between b = 0 and b = 2 (or b = 10) s/mm 2 images after removing visible vessels. IVIM analysis was performed with full fitting and segmented fitting, and with a threshold b ‐value of 60 or 200 s/mm 2 , and fitting started from b = 2 s/mm 2 . Thirty‐one men (age range: 25‐71 years) and 26 men (age: 22‐69 years) had DDVD and IVIM analysis, respectively, while 37 women (age: 20‐71 years) and 36 women (age: 20‐71 years) had DDVD and IVIM analysis, respectively. DDVD results showed a significant age‐related reduction for women. IVIM results for full fitting showed excellent agreement with those for segmented fitting using a threshold b of 60 s/mm 2 , but this was less good for results with a threshold b of 200 s/mm 2 . As age increased, female subjects' D slow measure showed a significant reduction, while their PF and D fast measures showed a significant increase. For the age group of 40‐55 years, DDVD(b0b2), DDVD(b0b10), D slow , PF and D fast were 12.26 ± 3.90 au/pixel, 16.95 ± 5.45 au/pixel, 1.072 ± 0.067 (10 −3 mm 2 /s), 0.141 ± 0.025 and 61.0 ± 14.0 (10 −3 mm 2 /s) for men, and 13.35 ± 3.6 au/pixel, 17.20 ± 3.62 au/pixel, 1.069 ± 0.074 (10 −3 mm 2 /s), 0.119 ± 0.014 and 57.1 ± 13.2 (10 −3 mm 2 /s) for women, respectively. DDVD measure of this study suggest that aging is associated with a reduction in liver perfusion. There is a possibility that a lower D slow measure is associated with artificially higher PF and D fast measures, and that IVIM modeling of the perfusion component is constrained by the diffusion component.