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Spectral editing in 1 H magnetic resonance spectroscopy: Experts' consensus recommendations
Author(s) -
Choi InYoung,
Andronesi Ovidiu C.,
Barker Peter,
Bogner Wolfgang,
Edden Richard A. E.,
Kaiser Lana G.,
Lee Phil,
Marjańska Małgorzata,
Terpstra Melissa,
Graaf Robin A.
Publication year - 2021
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4411
Subject(s) - homonuclear molecule , computer science , nuclear magnetic resonance , spectroscopy , spectral line , signal (programming language) , coupling (piping) , sequence (biology) , biological system , chemistry , physics , materials science , biology , biochemistry , organic chemistry , quantum mechanics , astronomy , molecule , metallurgy , programming language
Spectral editing in in vivo 1 H‐MRS provides an effective means to measure low‐concentration metabolite signals that cannot be reliably measured by conventional MRS techniques due to signal overlap, for example, γ‐aminobutyric acid, glutathione and D‐2‐hydroxyglutarate. Spectral editing strategies utilize known J ‐coupling relationships within the metabolite of interest to discriminate their resonances from overlying signals. This consensus recommendation paper provides a brief overview of commonly used homonuclear editing techniques and considerations for data acquisition, processing and quantification. Also, we have listed the experts' recommendations for minimum requirements to achieve adequate spectral editing and reliable quantification. These include selecting the right editing sequence, dealing with frequency drift, handling unwanted coedited resonances, spectral fitting of edited spectra, setting up multicenter clinical trials and recommending sequence parameters to be reported in publications.