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Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
Author(s) -
Krššák Martin,
Lindeboom Lucas,
SchrauwenHinderling Vera,
Szczepaniak Lidia S.,
Derave Wim,
Lundbom Jesper,
Befroy Douglas,
Schick Fritz,
Machann Jürgen,
Kreis Roland,
Boesch Chris
Publication year - 2021
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4266
Subject(s) - skeletal muscle , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , spectroscopy , chemistry , medicine , anatomy , physics , quantum mechanics
1 H‐MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of 1 H‐MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.