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Multiparametric classification of sub‐acute ischemic stroke recovery with ultrafast diffusion, 23 Na, and MPIO‐labeled stem cell MRI at 21.1 T
Author(s) -
Leftin Avigdor,
Rosenberg Jens T.,
Yuan Xuegang,
Ma Teng,
Grant Samuel C.,
Frydman Lucio
Publication year - 2020
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4186
Subject(s) - stroke (engine) , magnetic resonance imaging , effective diffusion coefficient , diffusion mri , medicine , imaging biomarker , stroke recovery , ischemic stroke , lesion , biomarker , brain ischemia , nuclear medicine , ischemia , radiology , pathology , chemistry , physics , biochemistry , rehabilitation , physical therapy , thermodynamics
MRI leverages multiple modes of contrast to characterize stroke. High‐magnetic‐field systems enhance the performance of these MRI measurements. Previously, we have demonstrated that individually sodium and stem cell tracking metrics are enhanced at ultrahigh field in a rat model of stroke, and we have developed robust single‐scan diffusion‐weighted imaging approaches that utilize spatiotemporal encoding (SPEN) of the apparent diffusion coefficient (ADC) for these challenging field strengths. Here, we performed a multiparametric study of middle cerebral artery occlusion (MCAO) biomarker evolution focusing on comparison of these MRI biomarkers for stroke assessment during sub‐acute recovery in rat MCAO models at 21.1 T. T 2 ‐weighted MRI was used as the benchmark for identification of the ischemic lesion over the course of the study. The number of MPIO‐induced voids measured by gradient‐recalled echo, the SPEN measurement of ADC, and 23 Na MRI values were determined in the ischemic area and contralateral hemisphere, and relative performances for stroke classification were compared by receiver operator characteristic analysis. These measurements were associated with unique time‐dependent trajectories during stroke recovery that changed the sensitivity and specificity for stroke monitoring during its evolution. Advantages and limitations of these contrasts, and the use of ultrahigh field for multiparametric stroke assessment, are discussed.