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Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer
Author(s) -
Sonkar Kanchan,
Ayyappan Vinay,
Tressler Caitlin M.,
Adelaja Oluwatobi,
Cai Ruoqing,
Cheng Menglin,
Glunde Kristine
Publication year - 2019
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4112
Subject(s) - phosphocholine , choline , phosphatidylcholine , choline kinase , phospholipid , biochemistry , phosphorylcholine , metabolism , chemistry , carcinogenesis , cancer , biology , membrane , gene , genetics
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer‐related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.