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MRI and MRS of intact perfused cancer cell metabolism, invasion, and stromal cell interactions
Author(s) -
Penet MarieFrance,
Shah Tariq,
Wildes Flonne,
Krishnamachary Balaji,
Bharti Santosh K.,
PachecoTorres Jesus,
Artemov Dmitri,
Bhujwalla Zaver M.
Publication year - 2019
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4053
Subject(s) - stromal cell , extracellular matrix , extracellular , cancer cell , cancer research , metabolism , cell , hypoxia (environmental) , cancer , cell metabolism , biology , microbiology and biotechnology , tumor microenvironment , cellular metabolism , pathology , chemistry , neuroscience , tumor cells , medicine , biochemistry , organic chemistry , oxygen , genetics
Because of the spatial and temporal heterogeneities of cancers, technologies to investigate cancer cells and the consequences of their interactions with abnormal physiological environments, such as hypoxia and acidic extracellular pH, with stromal cells, and with the extracellular matrix, under controlled conditions, are valuable to gain insights into the functioning of cancers. These insights can lead to an understanding of why cancers invade and metastasize, and identify effective treatment strategies. Here we have provided an overview of the applications of MRI/MRS/MRSI to investigate intact perfused cancer cells, their metabolism and invasion, and their interactions with stromal cells and the extracellular matrix.