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Glucagon infusion alters the hyperpolarized 13 C‐urea renal hemodynamic signature
Author(s) -
Qi Haiyun,
Mariager Christian Østergaard,
Nielsen Per Mose,
Schroeder Marie,
Lindhardt Jakob,
Nørregaard Rikke,
Klein Janet D.,
Sands Jeff M.,
Laustsen Christoffer
Publication year - 2019
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.4028
Subject(s) - urea , renal function , chemistry , glucagon , medicine , endocrinology , kidney , excretion , renal physiology , renal blood flow , biochemistry , insulin
Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handling; however, the exact mechanism has still to be fully understood. Here we investigate renal function and osmolite distribution using [ 13 C, 15 N] urea dynamics and 23 Na distribution before and 60 min after glucagon infusion in six female rats. Glucagon infusion increased the renal [ 13 C, 15 N] urea mean transit time by 14%, while no change was seen in the sodium distribution, glomerular filtration rate or oxygen consumption. This change is related to the well‐known effect of increased urea excretion associated with glucagon infusion, independent of renal functional effects. This study demonstrates for the first time that hyperpolarized 13 C‐urea enables monitoring of renal urinary excretion effects in vivo.