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Applications of high‐resolution magic angle spinning MRS in biomedical studies II—Human diseases
Author(s) -
Dietz Christopher,
Ehret Felix,
Palmas Francesco,
Vandergrift Lindsey A.,
Jiang Yanni,
Schmitt Vanessa,
Dufner Vera,
Habbel Piet,
Nowak Johannes,
Cheng Leo L.
Publication year - 2017
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3784
Subject(s) - metabolomics , high resolution , magic angle spinning , computational biology , chemistry , biology , bioinformatics , nuclear magnetic resonance spectroscopy , remote sensing , organic chemistry , geology
High‐resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high‐resolution spectra of non‐liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profiles present the possibility to improve identification and prognostication of various diseases and decipher the metabolomic impact of drug therapies. In this review, we evaluate HRMAS MRS results on human tissue specimens from malignancies and non‐localized diseases reported in the literature since the inception of the technique in 1996. We present the diverse applications of the technique in understanding pathological processes of different anatomical origins, correlations with in vivo imaging, effectiveness of therapies, and progress in the HRMAS methodology.