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An indirect method for in vivo T 2 mapping of [1‐ 13 C] pyruvate using hyperpolarized 13 C CSI
Author(s) -
Joe Eunhae,
Lee Hansol,
Lee Joonsung,
Yang Seungwook,
Choi YoungSuk,
Wang Eunkyung,
Song HoTaek,
Kim DongHyun
Publication year - 2017
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3690
Subject(s) - in vivo , imaging phantom , nuclear magnetic resonance , voxel , chemistry , a priori and a posteriori , physics , computer science , biology , optics , philosophy , microbiology and biotechnology , epistemology , artificial intelligence
An indirect method for in vivo T 2 mapping of 13 C–labeled metabolites using T 2 and T 2 * information of water protons obtained a priori is proposed. The T 2 values of 13 C metabolites are inferred using the relationship to T 2 ′ of coexisting 1 H and the T 2 * of 13 C metabolites, which is measured using routine hyperpolarized 13 C CSI data. The concept is verified with phantom studies. Simulations were performed to evaluate the extent of T 2 estimation accuracy due to errors in the other measurements. Also, bias in the 13 C T 2 * estimation from the 13 C CSI data was studied. In vivo experiments were performed from the brains of normal rats and a rat with C6 glioma. Simulation results indicate that the proposed method provides accurate and unbiased 13 C T 2 values within typical experimental settings. The in vivo studies found that the estimated T 2 of [1‐ 13 C] pyruvate using the indirect method was longer in tumor than in normal tissues and gave values similar to previous reports. This method can estimate localized T 2 relaxation times from multiple voxels using conventional hyperpolarized 13 C CSI and can potentially be used with time resolved fast CSI.