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Characterization of a rat orthotopic pancreatic head tumor model using three‐dimensional and quantitative multi‐parametric MRI
Author(s) -
Yin Ting,
Peeters Ronald,
Feng Yuanbo,
Liu Yewei,
Yu Jie,
Dymarkowski Steven,
Himmelreich Uwe,
Oyen Raymond,
Ni Yicheng
Publication year - 2017
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3676
Subject(s) - reproducibility , effective diffusion coefficient , nuclear medicine , dynamic contrast enhanced mri , medicine , repeatability , diffusion mri , magnetic resonance imaging , pathology , radiology , biomedical engineering , chemistry , chromatography
The purpose of this study was to investigate the reliability of 3D isotropic MRI and quantitative multi‐parametric MRI characterization on an orthotopic pancreatic head tumor model in rats. 3D isotropic T 2 ‐weighted MRI was performed as a routine for tumor longitudinal follow‐up and volume estimation. Common bile duct diameter was measured from 3D multiplanar reconstruction. Quantitative multi‐parametric measurements including pixel‐wise T 2 , T 1 relaxivity, apparent diffusion coefficient (ADC) and apparent diffusion kurtosis mapping were performed twice throughout tumor growth. Semi‐quantitative and quantitative analyses based on an extended Tofts model were applied to region‐of‐interest‐based dynamic contrast‐enhanced imaging, followed by contrast ratio measurement on standard contrast‐enhanced imaging. Moreover, low‐level texture‐based analysis was inspected for T 2 , T 1 , ADC and contrast ratio measurements. Results indicated that multi‐parametric MRI showed good reproducibility for tumor characterization; the measurements were not affected by tumor growth. Tumor growth was further confirmed with histology examinations. To conclude, state‐of‐the‐art clinical MRI techniques were translated to this preclinical tumor model with high reliability, and have paved the way for translational oncology studies on this tumor model.