Premium
Hyperpolarized 129 Xe MRI using isobutene as a new quenching gas
Author(s) -
Hodono Shota,
Imai Hirohiko,
Yamauchi Yukiko,
Kawamura Ayano,
Matsumoto Hironobu,
Okumura Shintaro,
Fujiwara Hideaki,
Kimura Atsuomi
Publication year - 2016
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3585
Subject(s) - xenon , chemistry , quenching (fluorescence) , isotopes of xenon , condensation , nuclear magnetic resonance , analytical chemistry (journal) , radiochemistry , chromatography , fluorescence , thermodynamics , physics , organic chemistry , quantum mechanics
The use of a quenching gas, isobutene, with a low vapor pressure was investigated to enhance the utility of hyperpolarized 129 Xe (HP Xe) MRI. Xenon mixed with isobutene was hyperpolarized using a home‐built apparatus for continuously producing HP Xe. The isobutene was then readily liquefied and separated almost totally by continuous condensation at about 173 K, because the vapor pressure of isobutene (0.247 kPa) is much lower than that of Xe (157 kPa). Finally, the neat Xe gas was continuously delivered to mice by spontaneous inhalation. The HP Xe MRI was enhanced twofold in polarization level and threefold in signal intensity when isobutene was adopted as the quenching gas instead of N 2 . The usefulness of the HP Xe MRI was verified by application to pulmonary functional imaging of spontaneously breathing mice, where the parameters of fractional ventilation ( r a ) and gas exchange ( f D ) were evaluated, aiming at future extension to preclinical studies. This is the first application of isobutene as a quenching gas for HP Xe MRI.