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Quantitative agreement between [ 15 O]H 2 O PET and model free QUASAR MRI‐derived cerebral blood flow and arterial blood volume
Author(s) -
Heijtel D.F.R.,
Petersen E.T.,
Mutsaerts H.J.M.M.,
Bakker E.,
Schober P.,
Stevens M.F.,
Berckel B.N.M,
Majoie C.B.L.M.,
Booij J.,
Osch M.J.P.,
Bavel E.T.,
Boellaard R.,
Lammertsma A.A.,
Nederveen A.J.
Publication year - 2016
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3480
Subject(s) - cerebral blood flow , nuclear medicine , quasar , positron emission tomography , blood flow , magnetic resonance imaging , white matter , medicine , nuclear magnetic resonance , physics , radiology , astrophysics , galaxy
The purpose of this study was to assess whether there was an agreement between quantitative cerebral blood flow (CBF) and arterial cerebral blood volume (CBVA) measurements by [ 15 O]H 2 O positron emission tomography (PET) and model‐free QUASAR MRI. Twelve healthy subjects were scanned within a week in separate MRI and PET imaging sessions, after which quantitative and qualitative agreement between both modalities was assessed for gray matter, white matter and whole brain region of interests (ROI). The correlation between CBF measurements obtained with both modalities was moderate to high ( r 2 : 0.28–0.60, P < 0.05), although QUASAR significantly underestimated CBF by 30% ( P < 0.001). CBV A was moderately correlated ( r 2 : 0.28–0.43, P < 0.05), with QUASAR yielding values that were only 27% of the [ 15 O]H 2 O‐derived values ( P < 0.001). Group‐wise voxel statistics identified minor areas with significant contrast differences between [ 15 O]H 2 O PET and QUASAR MRI, indicating similar qualitative CBV A and CBF information by both modalities. In conclusion, the results of this study demonstrate that QUASAR MRI and [ 15 O]H 2 O PET provide similar CBF and CBV A information, but with systematic quantitative discrepancies. Copyright © 2016 John Wiley & Sons, Ltd.