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Volumetric navigated MEGA‐SPECIAL for real‐time motion and shim corrected GABA editing
Author(s) -
Saleh Muhammad G.,
Alhamud A.,
Near Jamie,
Kouwe André J. W.,
Meintjes Ernesta M.
Publication year - 2016
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3454
Subject(s) - shim (computing) , subtraction , imaging phantom , computer science , motion (physics) , rotation around a fixed axis , artificial intelligence , biomedical engineering , physics , nuclear magnetic resonance , computer vision , chemistry , materials science , nuclear medicine , optics , mathematics , medicine , arithmetic , erectile dysfunction , classical mechanics
Mescher–Garwood (MEGA) editing with spin echo full intensity acquired localization (MEGA‐SPECIAL, MSpc) is a technique to acquire γ‐aminobutyric acid (GABA) without macromolecule (MM) contamination at a T E of 68 ms. However, due to the requirement of multiple shot‐localization, it is often susceptible to subject motion and B 0 inhomogeneity. A method is presented for real‐time shim and motion correction (ShMoCo) using volumetric navigators to correct for motion and motion‐related B 0 inhomogeneity during MSpc acquisition. A phantom experiment demonstrates that ShMoCo restores the GABA peak and improves spectral quality in the presence of motion and zero‐ and first‐order shim changes. The ShMoCo scans were validated in three subjects who performed up–down and left–right head rotations. Qualitative assessment of these scans indicates effective reduction of subtraction artefacts and well edited GABA peaks, while quantitative analysis indicates superior fitting and spectral quality relative to scans with no correction. Copyright © 2015 John Wiley & Sons, Ltd.