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Does superficial fat affect metabolite concentrations determined by MR spectroscopy with water referencing?
Author(s) -
Kyathanahally S. P.,
Fichtner N. D.,
Adalid V.,
Kreis R.
Publication year - 2015
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3419
Subject(s) - metabolite , attenuation , nuclear magnetic resonance , spectroscopy , signal (programming language) , nuclear magnetic resonance spectroscopy , echo (communications protocol) , chemistry , magnetic resonance imaging , in vivo magnetic resonance spectroscopy , physics , computer science , medicine , biochemistry , radiology , optics , computer network , quantum mechanics , programming language
It has recently been reported in this journal that local fat depots produce a sizable frequency‐dependent signal attenuation in magnetic resonance spectroscopy (MRS) of the brain. If of a general nature, this effect would question the use of internal reference signals for quantification of MRS and the quantitative use of MRS as a whole. Here, it was attempted to verify this effect and pinpoint the potential causes by acquiring data with various acquisition settings, including two field strengths, two MR scanners from different vendors, different water suppression sequences, RF coils, localization sequences, echo times, and lipid/metabolite phantoms. With all settings tested, the reported effect could not be reproduced, and it is concluded that water referencing and quantitative MRS per se remain valid tools under common acquisition conditions. Copyright © 2015 John Wiley & Sons, Ltd.