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Multiparametric MRI as an early biomarker of individual therapy effects during concomitant treatment of brain tumours
Author(s) -
Lemasson Benjamin,
Bouchet Audrey,
Maisin Cécile,
Christen Thomas,
Le Duc Géraldine,
Rémy Chantal,
Barbier Emmanuel L.,
Serduc Raphaël
Publication year - 2015
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3357
Subject(s) - medicine , radiation therapy , concomitant , nuclear medicine , imaging biomarker , magnetic resonance imaging , multiparametric mri , microvessel , urology , pathology , prostate cancer , radiology , cancer , immunohistochemistry
The aim of this study was to determine the ability of multiparametric MRI to identify the early effects of individual treatment, during combined chemo‐radiotherapy on brain tumours. Eighty male rats bearing 9L gliosarcomas were randomized into four groups: untreated, anti‐angiogenic therapy (SORA group), microbeam radiation therapy (MRT group) and both treatments (MRT+SORA group). Multiparametric MRI (tumour volume, diffusion‐weighted MR imaging (ADC), blood volume fraction (BVf), microvessel index (VSI), vessel wall integrity (AUC P846 ) and tissue oxygen saturation (StO 2 )) was performed 1 day before and 2, 5 and 8 days after treatment initiation. Unpaired t ‐tests and one‐way ANOVA were used for statistical analyses. Each MR parameter measured in our protocol was revealed to be sensitive to tumour changes induced by any of the therapies used (individually or combined). When compared with untreated tumours, SORA induced a decrease in BVf, VSI, StO 2 and AUC P846 , MRT generated an increase in ADC and AUC P846 and combined therapies yielded mixed effects: an increase in ADC and AUC P846 and a decrease in BVf, StO 2 and AUC P846 . MRT and MRT+SORA significantly slowed tumour growth. Despite these two groups presenting with similar tumour sizes, the information yielded from MR multiparameter assessment indicated that, when used concomitantly, each therapy induced distinguishable and appreciable physiological changes in the tumour. Our results suggest that multiparametric MRI can monitor the effects of individual treatments, used concomitantly, on brain tumours. Such monitoring would be useful for the detection of tumour resistance to drug/radiotherapy in patients undergoing concomitant therapies. Copyright © 2015 John Wiley & Sons, Ltd.