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Sodium MRI of glioma in animal models at ultrahigh magnetic fields
Author(s) -
Schepkin Victor D.
Publication year - 2016
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3347
Subject(s) - glioma , magnetic resonance imaging , sodium , medicine , diffusion mri , nuclear magnetic resonance , chemistry , cancer research , radiology , physics , organic chemistry
High magnetic fields expand our capability to use sodium MRI for biomedical applications. The central goal of this review is devoted to the unique features of sodium MRI in tumor animal models, mainly in glioma, performed at 9.4 and 21.1 T. The ability of sodium MRI to monitor tumor response to therapy was evaluated. It is noteworthy that sodium MRI can detect glioma response to chemotherapy earlier than diffusion MRI. Especially attractive is the ability of sodium MRI to predict tumor therapeutic resistance before therapy. The non‐invasive prediction of tumor chemo‐resistance by sodium MRI presents a potential to individualize strategies for cancer treatment. Specifics of sodium MRI and technical aspects of imaging are also presented. Copyright © 2015 John Wiley & Sons, Ltd.