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Simultaneous imaging of 13 C metabolism and 1 H structure: technical considerations and potential applications
Author(s) -
Gordon Jeremy W.,
Fain Sean B.,
Niles David J.,
Ludwig Kai D.,
Johnson Kevin M.,
Peterson Eric T.
Publication year - 2015
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3279
Subject(s) - imaging phantom , physics , nuclear magnetic resonance , computer science , artificial intelligence , chemistry , optics
Real‐time imaging of 13 C metabolism in vivo has been enabled by recent advances in hyperpolarization. As a result of the inherently low natural abundance of endogenous 13 C nuclei, hyperpolarized 13 C images lack structural information that could be used to aid in motion detection and anatomical registration. Motion before or during the 13 C acquisition can therefore result in artifacts and misregistration that may obscure measures of metabolism. In this work, we demonstrate a method to simultaneously image both 1 H and 13 C nuclei using a dual‐nucleus spectral–spatial radiofrequency excitation and a fully coincident readout for rapid multinuclear spectroscopic imaging. With the appropriate multinuclear hardware, and the means to simultaneously excite and receive on both channels, this technique is straightforward to implement requiring little to no increase in scan time. Phantom and in vivo experiments were performed with both Cartesian and spiral trajectories to validate and illustrate the utility of simultaneous acquisitions. Motion compensation of dynamic metabolic measurements acquired during free breathing was demonstrated using motion tracking derived from 1 H data. Simultaneous multinuclear imaging provides structural 1 H and metabolic 13 C images that are correlated both spatially and temporally, and are therefore amenable to joint 1 H and 13 C analysis and correction of structure–function images. Copyright © 2015 John Wiley & Sons, Ltd.