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Phase‐contrast helium‐3 MRI of aerosol deposition in human airways
Author(s) -
Sarracanie Mathieu,
Grebenkov Denis,
Sandeau Julien,
Coulibaly Soulé,
Martin Andrew R.,
Hill Kyle,
Pérez Sánchez José Manuel,
Fodil Redouane,
Martin Lionel,
Durand Emmanuel,
Caillibotte Georges,
Isabey Daniel,
Darrasse Luc,
Bittoun Jacques,
Maître Xavier
Publication year - 2015
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3238
Subject(s) - aerosol , deposition (geology) , imaging phantom , helium , respiratory tract , environmental science , materials science , chemistry , nuclear medicine , respiratory system , medicine , structural basin , geology , paleontology , organic chemistry
One of the key challenges in the study of health‐related aerosols is predicting and monitoring sites of particle deposition in the respiratory tract. The potential health risks of ambient exposure to environmental or workplace aerosols and the beneficial effects of medical aerosols are strongly influenced by the site of aerosol deposition along the respiratory tract. Nuclear medicine is the only current modality that combines quantification and regional localization of aerosol deposition, and this technique remains limited by its spatial and temporal resolutions and by patient exposure to radiation. Recent work in MRI has shed light on techniques to quantify micro‐sized magnetic particles in living bodies by the measurement of associated static magnetic field variations. With regard to lung MRI, hyperpolarized helium‐3 may be used as a tracer gas to compensate for the lack of MR signal in the airways, so as to allow assessment of pulmonary function and morphology. The extrathoracic region of the human respiratory system plays a critical role in determining aerosol deposition patterns, as it acts as a filter upstream from the lungs. In the present work, aerosol deposition in a mouth–throat phantom was measured using helium‐3 MRI and compared with single‐photon emission computed tomography. By providing high sensitivity with high spatial and temporal resolutions, phase‐contrast helium‐3 MRI offers new insights for the study of particle transport and deposition. Copyright © 2014 John Wiley & Sons, Ltd.