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Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced‐field‐of‐view turbo spin echo at 3.0 T
Author(s) -
Liu Qi,
Jin Ning,
Fan Zhaoyang,
Natsuaki Yutaka,
Tawackoli Wafa,
Pelled Gadi,
Bae Hyun,
Gazit Dan,
Li Debiao
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.3001
Subject(s) - fast spin echo , reproducibility , intervertebral disc , biomedical engineering , nuclear magnetic resonance , imaging phantom , chemistry , magnetic resonance imaging , materials science , nuclear medicine , medicine , anatomy , radiology , physics , chromatography
The reduced field‐of‐view (rFOV) turbo‐spin‐echo (TSE) technique, which effectively suppresses bowel movement artifacts, is developed for the purpose of chemical exchange saturation transfer (CEST) imaging of the intervertebral disc (IVD) in vivo . Attempts to quantify IVD CEST signals in a clinical setting require high reliability and accuracy, which is often compromised in the conventionally used technique. The proposed rFOV TSE CEST method demonstrated significantly superior reproducibility when compared with the conventional technique on healthy volunteers, implying it is a more reliable measurement. Phantom study revealed a linear relation between CEST signal and glycosaminoglycan (GAG) concentration. The feasibility of detecting IVD degeneration was demonstrated on a healthy volunteer, indicating that the proposed method is a promising tool to quantify disc degeneration. Copyright © 2013 John Wiley & Sons, Ltd.