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In vivo MRI cell tracking using perfluorocarbon probes and fluorine‐19 detection
Author(s) -
Ahrens Eric T.,
Zhong Jia
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.2948
Subject(s) - in vivo , ex vivo , cell , tracking (education) , chemistry , biomedical engineering , medicine , biology , biochemistry , psychology , pedagogy , microbiology and biotechnology
This article presents a brief review of preclinical in vivo cell‐tracking methods and applications using perfluorocarbon (PFC) probes and fluorine‐19 ( 19 F) MRI detection. Detection of the 19 F signal offers high cell specificity and quantification ability in spin density‐weighted MR images. We discuss the compositions of matter, methods and applications of PFC‐based cell tracking using ex vivo and in situ PFC labeling in preclinical studies of inflammation and cellular therapeutics. We also address the potential applicability of 19 F cell tracking to clinical trials. Copyright © 2013 John Wiley & Sons, Ltd.