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Nuts and bolts of chemical exchange saturation transfer MRI
Author(s) -
Liu Guanshu,
Song Xiaolei,
Chan Kannie W. Y.,
McMahon Michael T.
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.2899
Subject(s) - computer science , contrast (vision) , saturation (graph theory) , artificial intelligence , mathematics , combinatorics
Chemical exchange saturation transfer (CEST) has emerged as a novel MRI contrast mechanism that is well suited for molecular imaging studies. This new mechanism can be used to detect small amounts of contrast agent through the saturation of rapidly exchanging protons on these agents, allowing a wide range of applications. CEST technology has a number of indispensable features, such as the possibility of simultaneous detection of multiple ‘colors’ of agents and of changes in their environment (e.g. pH, metabolites, etc.) through MR contrast. Currently, a large number of new imaging schemes and techniques are being developed to improve the temporal resolution and specificity and to correct for the influence of B 0 and B 1 inhomogeneities. In this review, the techniques developed over the last decade are summarized with the different imaging strategies and post‐processing methods discussed from a practical point of view, including the description of their relative merits for the detection of CEST agents. The goal of the present work is to provide the reader with a fundamental understanding of the techniques developed, and to provide guidance to help refine future applications of this technology. This review is organized into three main sections (‘Basics of CEST contrast’, ‘Implementation’ and ‘Post‐processing’), and also includes a brief Introduction and Summary. The ‘Basics of CEST contrast’ section contains a description of the relevant background theory for saturation transfer and frequency‐labeled transfer, and a brief discussion of methods to determine exchange rates. The ‘Implementation’ section contains a description of the practical considerations in conducting CEST MRI studies, including the choice of magnetic field, pulse sequence, saturation pulse, imaging scheme, and strategies to separate magnetization transfer and CEST. The ‘Post‐processing’ section contains a description of the typical image processing employed for B 0 / B 1 correction, Z ‐spectral interpolation, frequency‐selective detection and improvement of CEST contrast maps. Copyright © 2013 John Wiley & Sons, Ltd.