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NMR of hyperpolarised probes
Author(s) -
Witte Christopher,
Schröder Leif
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.2873
Subject(s) - molecular imaging , nanotechnology , computer science , chemistry , nuclear magnetic resonance , biological system , materials science , physics , biology , in vivo , microbiology and biotechnology
Increasing the sensitivity of NMR experiments is an ongoing field of research to help realise the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a powerful approach that enables the use of NMR for molecular and cellular imaging. Substantial progress has been achieved over recent years in terms of both tracer preparation and detection schemes. This review summarises recent developments in probe design and optimised signal encoding, and promising results in sensitive disease detection and efficient therapeutic monitoring. The different methods have great potential to provide molecular specificity not available by other diagnostic modalities. Copyright © 2012 John Wiley & Sons, Ltd.