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Multimodal iron oxide nanoparticles for hybrid biomedical imaging
Author(s) -
Heidt Timo,
Nahrendorf Matthias
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.2872
Subject(s) - iron oxide nanoparticles , iron oxide , nanotechnology , nanoparticle , molecular imaging , optical imaging , modalities , materials science , merge (version control) , computer science , biomedical engineering , chemistry , medicine , in vivo , physics , optics , social science , microbiology and biotechnology , information retrieval , sociology , metallurgy , biology
Iron oxide core nanoparticles are attractive imaging agents because their material properties allow the tuning of pharmacokinetics as well as the attachment of multiple moieties to their surface. In addition to affinity ligands, these include fluorochromes and radioisotopes for detection with optical and nuclear imaging. As the iron oxide core can be detected by MRI, options for combining imaging modalities are manifold. Already, preclinical imaging strategies have combined noninvasive imaging with higher resolution techniques, such as intravital microscopy, to gain unprecedented insight into steady‐state biology and disease. Going forward, hybrid iron oxide nanoparticles will help to merge modalities, creating a synergy that will enable imaging in basic research and, potentially, also in the clinic. Copyright © 2012 John Wiley & Sons, Ltd.