Premium
Noninvasive quantification of intracellular sodium in human brain using ultrahigh–field MRI
Author(s) -
Fleysher Lazar,
Oesingmann Niels,
Brown Ryan,
Sodickson Daniel K.,
Wiggins Graham C.,
Inglese Matilde
Publication year - 2013
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.2813
Subject(s) - sodium , intracellular , magnetic resonance imaging , in vivo , extracellular , human brain , chemistry , extracellular fluid , brain tissue , quantitative analysis (chemistry) , nuclear magnetic resonance , biomedical engineering , biology , medicine , biochemistry , chromatography , neuroscience , radiology , physics , microbiology and biotechnology , organic chemistry
In vivo sodium magnetic resonance imaging (MRI) measures tissue sodium content in living human brain but current methods do not allow noninvasive quantitative assessment of intracellular sodium concentration (ISC) – the most useful marker of tissue viability. In this study, we report the first noninvasive quantitative in vivo measurement of ISC and intracellular sodium volume fraction (ISVF) in healthy human brain, made possible by measuring tissue sodium concentration (TSC) and intracellular sodium molar fraction (ISMF) at ultra‐high field MRI. The method uses single–quantum (SQ) and triple–quantum filtered (TQF) imaging at 7 Tesla to separate intra‐ and extracellular sodium signals and provide quantification of ISMF, ISC and ISVF. This novel method allows noninvasive quantitative measurement of ISC and ISVF, opening many possibilities for structural and functional metabolic studies in healthy and diseased brains. Copyright © 2012 John Wiley & Sons, Ltd.