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Preliminary observations of transverse relaxation rates obtained at 3 Tesla from the substantia nigra of adult normal human brain
Author(s) -
Helpern J. A.,
Gorell J. M.,
Deniau J. C.,
Welch K. M. A.,
Ordidge R. J.
Publication year - 1995
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940080106
Subject(s) - substantia nigra , midbrain , nuclear magnetic resonance , relaxation (psychology) , transverse plane , diffusion , chemistry , anatomy , physics , biology , endocrinology , neuroscience , thermodynamics , dopamine , central nervous system , dopaminergic
The transverse relaxation rates R 2 and R *2 were measured at 3 T in the substantia nigra of the midbrain of adult normal human controls. The relaxation rate arising from magnetic inhomogeneities, R 2 ′, was calculated from the relationship R*2=R 2 +R 2 ′. No significant differences were found for any parameters between left and right side substantia nigral regions, however, a significant inverse correlation was found between R 2 and R 2 ′ (r=0.70, p=0.035). Water diffusion, in the presence of paramagnetic metal ions, may play a role in determining the relative contributions to reversible and irreversible transverse relaxation and may explain the inverse correlation demonstrated here.