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Inflow versus deoxyhemoglobin effects in bold functional MRI using gradient echoes at 1.5 T
Author(s) -
Duyn Jeff H.,
Moonen Chrit T. W.,
van Yperen Gert H.,
de Boer Ruud W.,
Luyten Peter R.
Publication year - 1994
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940070113
Subject(s) - inflow , gradient echo , functional imaging , flip angle , functional magnetic resonance imaging , nuclear magnetic resonance , blood oxygenation , functional connectivity , dynamic functional connectivity , neuroscience , magnetic resonance imaging , physics , psychology , medicine , mechanics , radiology
Modified gradient‐echo MR techniques were applied to study the effects of inflow on functional brain imaging studies using visual and motor cortex stimulation. The results demonstrate that the large signal changes, seen in previously reported gradient‐echo studies at 1.5–2.0 T, are dominated by direct inflow effects, in particular when using a large flip angle and a thin slice. The findings suggest that inflow‐based functional imaging, along with Blood Oxygenation Level Dependent (BOLD) functional MRI, may play an important role in future research towards the functional organization of the human brain.