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In vivo 19 F one‐dimensional chemical shift imaging study of isoflurane uptake in rabbit brain
Author(s) -
Venkatasubramanian P. N.,
Shen Y. J.,
Wyrwicz A. M.
Publication year - 1993
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940060605
Subject(s) - isoflurane , in vivo , pulse (music) , anesthetic , chemistry , diffusion , brain tissue , nuclear magnetic resonance , anesthesia , biophysics , anatomy , biology , medicine , physics , microbiology and biotechnology , organic chemistry , detector , optics , thermodynamics
19 F one‐dimensional chemical shift imaging and one‐pulse techniques were used to follow the uptake of isoflurane in rabbit brain in vivo . Brain isoflurane appeared mainly in two adjacent slices of cerebral cortex. Both slices showed increase in anesthetic content at similar rates. A biphasic first‐order uptake pattern with an initial fast component and a slower rate for the duration of the uptake was observed by the one‐pulse technique. Only the slower kinetic was followed by chemical shift imaging due to constraints on temporal resolution. Anesthetic levels in arterial blood reached equilibrium significantly earlier than in brain, suggesting a ‚restricted’ diffusion into brain tissue for this agent.