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Proton‐decoupled 31 P chemical shift imaging of the human brain in normal volunteers
Author(s) -
MurphyBoesch Joseph,
Stoyanova Radka,
Srinivasan Ravi,
Willard Tamela,
Vigneron Daniel,
Nelson Sarah,
Taylor June S.,
Brown Truman R.
Publication year - 1993
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940060302
Subject(s) - nuclear magnetic resonance , proton , chemistry , spectral line , shim (computing) , excitation , analytical chemistry (journal) , physics , medicine , chromatography , quantum mechanics , astronomy , erectile dysfunction
Proton‐decoupled, 31 P three‐dimensional (3‐D) chemical shift imaging (CSI) spectra have been acquired from the entire human brain using a new dual tuned resonator. The resonator operates in quadrature mode to provide improved sensitivity, excellent B 1 homogeneity, and reduced power deposition at both frequencies. Proton‐decoupled and fully NOE enhanced, 31 P spectra were acquired from normal volunteers using Waltz‐4 proton decoupling with continuous wave bi‐level excitation applied through a second radio frequency channel. Well resolved peaks in the phosphomonoester (PME) and phosphodiester regions were obtained from non‐localized FIDs and spectra localized with 3‐D CSI without processing for resolution enhancement. pH measurements made over large regions of the brain using the P i resonance show no significant variations (6.9±0.02) for a single individual. The improved spectral resolution and sensitivity of the PME resonances results in more well defined metabolite images of the PME peak region.