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Biological applications for small solenoids: NMR spectroscopy of microliter volumes at high fields
Author(s) -
Wiseman Robert W.,
Moerland Timothy S.,
Kushmerick Martin J.
Publication year - 1993
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940060208
Subject(s) - nuclear magnetic resonance spectroscopy , spectroscopy , nuclear magnetic resonance , chemistry , analytical chemistry (journal) , materials science , chromatography , physics , quantum mechanics
In this paper we describe features of an NMR probe designed for the study of small, superfused muscles. We also present the results of an empirical study of the performance characteristics of several configurations of small solenoid coils, ca 2 mm diameter. Our data show that optimal use of the available volume of sample becomes the prime consideration in coil design at this scale. In contrast to large biological samples, for such small coils the equivalent resistance associated with the sample is minor relative to the resistance of the RF coil itself. Thus, substantial improvements in the S/N ratio can be obtained by adopting coil configurations that are inferior electrically, but which can sample a greater volume of tissue.