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Phospholipid metabolites as indicators of cancer cell function
Author(s) -
RuizCabello Jesús,
Cohen Jack S.
Publication year - 1992
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940050506
Subject(s) - phospholipid , metabolite , in vivo , function (biology) , cancer , biochemistry , cancer cell , metabolism , nuclear magnetic resonance spectroscopy , chemistry , computational biology , biology , biophysics , microbiology and biotechnology , stereochemistry , genetics , membrane
NMR methods are being applied to study phospholipid metabolism of cancer cells by monitoring the resonances which appear in the 31 P spectrum. This review, aside from considering the applicability of NMR to this specific pathway, raises the question of whether the phospholipid metabolite peaks observed by MR are indicators of cancer cell function or tumor response to treatment. After assessing the results from many investigations, it is concluded that there is no clear correlation and that a combination of techniques, including in vitro and extract studies, will be necessary for a more comprehensive evaluation of the in vivo data.