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In vivo 1 H, 31 P‐{ 1 H} and 13 C‐{ 1 H} magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man
Author(s) -
Bachert Peter,
Bellemann Matthias E.,
Layer Günter,
Koch Thomas,
Semmler Wolfhard,
Lorenz Walter J.
Publication year - 1992
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940050402
Subject(s) - spectroscopy , physics , resonance (particle physics) , nuclear magnetic resonance , chemistry , radiochemistry , atomic physics , quantum mechanics
Human tumor and skeletal muscle tissue was studied by means of in vivo 1 H, 31 P, and 13 C MRS. The examinations were performed with a 1.5 T whole‐body MR scanner equipped with a second RF system. Localized 1 H and broadband proton‐decoupled 31 P and 13 C MR spectra were obtained in measurement times of 5, 10 and 33 min, respectively, from a malignant fibrous histiocytoma in a patient and from gastrocnemius muscle tissue in healthy volunteers. Proton decoupling enhanced the sensitivity (via the nuclear Overhauser effect) and the information available from in vivo 31 P and 13 C MR spectra significantly. The most information was obtained from 1 H‐decoupled 31 P spectra. Observation of more than one spin species allows peak assignments to be verified mutually. The spectral data of the histiocytoma differ largely from that of muscle tissue and show a tumor with elevated pH value, normal level of nucleoside 5′‐triphosphates, and high level of compounds involved in phospholipid turnover. The multinuclear in vivo MRS experiment may allow the non‐invasive observation of almost the complete pathway of phospholipid synthesis and degradation in intact human tissue.