Premium
Multiple quantum NMR spectroscopy methods for measuring the apparent self‐diffusion coefficient of In Vivo lactic acid
Author(s) -
Sotak Christopher H.
Publication year - 1991
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940040207
Subject(s) - lactic acid , in vivo , diffusion , nuclear magnetic resonance , spectroscopy , nuclear magnetic resonance spectroscopy , effective diffusion coefficient , chemistry , self diffusion , in vivo magnetic resonance spectroscopy , analytical chemistry (journal) , magnetic resonance imaging , bacteria , physics , chromatography , biology , computer science , thermodynamics , medicine , genetics , microbiology and biotechnology , self service , computer security , radiology , quantum mechanics
Nuclear magnetic resonance spectroscopy methods are presented for measuring the apparent self‐diffusion coefficient of lactic acid in vivo. These techniques incorporate diffusion‐sensitive gradients into multiple quantum NMR pulse sequences that are employed for spectral editing. Both diffusion‐sensitive zero quantum (ZQ) and double quantum (DQ) spectral editing techniques have been developed and the DQ method has been used to measure the apparent self‐diffusion coefficient of in vivo lactic acid in H‐MESO‐1 human tumor xenografts subcutaneously implanted in athymic mice.