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Acquisition and quantitation in proton spectroscopy
Author(s) -
Luyten Peter R.,
Mariën Ad J. H.,
Den Hollander A.
Publication year - 1991
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940040206
Subject(s) - nuclear magnetic resonance , human brain , nuclear magnetic resonance spectroscopy , spectroscopy , creatine , choline , resolution (logic) , chemistry , in vivo , proton , in vivo magnetic resonance spectroscopy , image resolution , functional magnetic resonance spectroscopy of the brain , resting state fmri , computer science , magnetic resonance imaging , physics , neuroscience , medicine , biochemistry , biology , artificial intelligence , radiology , microbiology and biotechnology , quantum mechanics
Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the 1 H NMR signal, a spatial resolution of 7 × 7 × 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N‐acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.