Premium
Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo . Preliminary observations on tumor grading
Author(s) -
Arnold D. L.,
Shoubridge E. A.,
Villemure J.G.,
Feindel W.
Publication year - 1990
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940030407
Subject(s) - nuclear magnetic resonance , creatine , proton magnetic resonance , in vivo , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , grading (engineering) , spectroscopy , choline , pulse sequence , chemistry , nuclear medicine , pathology , medicine , biology , radiology , physics , biochemistry , ecology , microbiology and biotechnology , quantum mechanics
We have obtained localized, water‐suppressed proton magnetic resonance spectra from eleven astrocytomas in vivo . Localized phosphorus spectra were also obtained from three of these tumors. All tumors were examined prior to surgery, radiotherapy or chemotherapy. Examinations were performed with a commercially available 1.5 Tesla combined imaging and spectroscopy system using a stimulated echo pulse sequence for protons and an ISIS pulse sequence for phosphorus. A relatively high lactate resonance intensity correlated with a more malignant histological tumor grade and more aggressive behaviour. The resonance intensity of N ‐acetylaspartate/creatine was decreased and choline/creatine was increased, but these did not reliably discriminate between tumor grades. Other unidentified resonances not present in spectra of normal brain were sometimes seen. Proton magnetic resonance spectroscopy provides a new method for determining the metabolic behaviour of astrocytomas that may be useful in the clinical assessment of patients with these tumors.