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In vivo 1 values of phosphorus metabolites in human liver and muscle determined at 1.5T by chemical shift imaging
Author(s) -
Buchthal S. D.,
Thoma W. J.,
Taylor J. S.,
Nelson S. J.,
Brown T. R.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020520
Subject(s) - phosphocreatine , nuclear magnetic resonance , phosphomonoesters , spectral line , chemistry , in vivo , analytical chemistry (journal) , spectroscopy , resolution (logic) , phosphate , inorganic phosphate , physics , chromatography , biochemistry , biology , quantum mechanics , astronomy , endocrinology , artificial intelligence , computer science , energy metabolism , microbiology and biotechnology
A procedure for obtaining T 1 values for phosphorous metabolites in localized regions of human subjects, using a standard 1.5 T MR imager, is described. 31 P spectra and T 1 values localized to the liver, and to abdominal and calf muscle of healthy volunteers were obtained by means of a multi‐slice spectroscopy technique, consisting of a chemical shift imaging (CSI) sequence with a B 1 ‐insensitive excitation and one dimension of phase encoding, used in conjunction with a surface coil. An examination consisting of proton imaging, shimming and collection of 31 P progressive saturation spectroscopic data for T 1 determination required 1h to perform. Shimming on the signal from the body region detected by the surface coil gave spectra of excellent spectral resolution. Quantification of all peaks in the localized 31 P spectra was carried out with the PIQABLE algorithm, and T 1 values were calculated for inorganic phosphate (P i ), the phosphodiester region, and the ATP α‐, b̃‐ and γ peaks of liver, and for calf muscle P i , phosphocreatine (PCr), and the three ATP peaks. The precisions of the measurement and of the entire process for obtaining and quantifying localized spectra by one‐dimensional CSI were determined, and the accuracy of T 1 values obtained by this means was verified. The temporal variation in T 1 values obtained in a series of examinations of a single normal subject was also assessed. The consistency of the T 1 values obtained in this study with in vivo T 1 values obtained by other techniques is a stringent test of accuracy of localized spectra obtained with CSI.