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1 H NMR study of cerebral development in the rat
Author(s) -
Bates T. E.,
Williams S. R.,
Gadian D. G.,
Bell J. D.,
Small R. K.,
Iles R. A.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020509
Subject(s) - creatine , choline , taurine , nuclear magnetic resonance spectroscopy , brain development , period (music) , chemistry , medicine , endocrinology , biology , biochemistry , stereochemistry , neuroscience , physics , acoustics , amino acid
1 H NMR spectroscopy of brain extracts was used to investigate the metabolic changes that take place during development of the neonatal rat brain. Data were obtained over the range 1–21 days. The concentration of N ‐acetylaspartate rose by a factor of 9 during this period, the most rapid rise occurring after day 9. The total creatine concentration rose from days 1–21, with a large increase between days 1 and 5. Taurine concentration rose until day 5, then fell from days 5–21. The concentration of choline‐containing compounds fell during the 21 day period. The results are discussed in relation to brain development and conventional biochemical data. A major conclusion in relation to spectroscopy of children is that interpretation of changes seen in disease will require adequate data from age‐matched controls.