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The importance of the voxel size in clinical 1 H spectroscopy of the human brain
Author(s) -
Ernst Th.,
Hennig J.,
Ott D.,
Friedburg H.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020508
Subject(s) - voxel , homogeneity (statistics) , nuclear magnetic resonance , human brain , spectral line , in vivo magnetic resonance spectroscopy , spectroscopy , multiple sclerosis , chemistry , nuclear medicine , physics , magnetic resonance imaging , biology , medicine , mathematics , radiology , neuroscience , statistics , astronomy , quantum mechanics , immunology
It is demonstrated that it is possible to acquire two volume selective 1 H NMR spectra of human brain in vivo , consisting of voxels of 1.5 × 1.5 × 1.5 cm 3 , within 14 min with a good S/N ratio. This is mainly achieved by the application of a PRESS sequence generating a spin‐echo of the VOI at 135 ms in conjunction with the STABLE technique by which two spectra can be recorded in an interlaced mode. The B o homogeneity over such small voxels is considerably higher than over larger voxels. With these methodological improvements it is possible to observe morphological heterogeneity of tumors. The results indicate that spectral changes seem to correlate with the metabolic state of the tumor rather than the tumor type. Additionally the spectrum of a patient with multiple sclerosis suggests that even differentiation between tumors and other lesions might not be possible.