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Brain metabolites as 1 H NMR markers of neuronal and glial disorders
Author(s) -
Gill S. S.,
Small R. K.,
Thomas D. G. T.,
Patel P.,
Porteous R.,
Van Bruggen N.,
Gadian D. G.,
Kauppinen R. A.,
Williams S. R.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020505
Subject(s) - phosphocreatine , in vivo , nuclear magnetic resonance spectroscopy , creatine , choline , astrocyte , human brain , chemistry , nuclear magnetic resonance , biology , biochemistry , neuroscience , central nervous system , endocrinology , energy metabolism , stereochemistry , physics , microbiology and biotechnology
1 H NMR spectroscopy of human brain in vivo can be used to detect a number of cerebral metabolites including N ‐acetylaspartate, creatine + phosphocreatine and choline‐containing compounds. We have used 1 H NMR spectroscopy to analyse these signals in (i) biopsy material from both normal human brain and astrocytomas, and (ii) primary astrocyte cultures. On the basis of this analysis, we conclude that in vivo 1 H NMR spectroscopy could play an important clinical role in the non‐invasive assessment of neuronal degeneration and proliferation of non‐neuronal cells.