Premium
Localized NMR spectroscopy In vivo . Progress and problems
Author(s) -
Frahm Jens,
Michaelis Thomas,
Merboldt KlausDietmar,
Hänicke Wolfgang,
Gyngell Michael L.,
Chien Daisy,
Bruhn Harald
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020504
Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , in vivo , spectroscopy , in vivo magnetic resonance spectroscopy , chemistry , materials science , physics , medicine , magnetic resonance imaging , biology , radiology , genetics , quantum mechanics
Metabolites in brain and muscle of normal human volunteers have been studied by localized 1 H and 31 P NMR spectroscopy in vivo. Localization was achieved by means of stimulated echo (STEAM) sequences for both water‐suppressed 1 H NMR (TE = 20 ms) and 31 P NMR (TE = 3 ms). Volumes‐of‐interest and measuring times selected for brain spectroscopy were 8 mL and 6.5 min for 1 H NMR and 125 mL and 13 min for 31 P NMR, respectively. General problems relating to spatial localization, spectral resolution, and quantitation of in vivo NMR data are discussed with respect to the nucleus and organs under investigation. They are correlated to studies of tissue extracts obtained at field strengths of 2.35 T (Bruker Biospec) and 7.0 T (Bruker MSL 300). Human studies were performed at 2.0 T on a whole‐body research system (Siemens Magnetom).