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Characterization of the spleen by In vivo image guided 31 P magnetic resonance spectroscopy
Author(s) -
Smith Stephen R.,
Martin Peter A.,
Davies John M.,
Edwards Richard H. T.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020407
Subject(s) - phosphomonoesters , phosphodiester bond , in vivo , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , spleen , nuclear magnetic resonance , chemistry , pathology , malignancy , lymphoma , in vivo magnetic resonance spectroscopy , nuclear medicine , medicine , biology , biochemistry , radiology , phosphate , inorganic phosphate , stereochemistry , rna , physics , microbiology and biotechnology , gene
Abstract Image localized 31 P magnetic resonance spectroscopy of the spleen was performed in six normal volunteers, 13 patients with splenomegaly due to haematological malignancies, and two patients with benign causes of splenomegaly. The malignant disorders had elevated phosphomonoesters (PME) compared to controls, probably due to increased turnover of membrane phospholipids, with variable alterations in high energy phosphates. There appeared to be no relationship between grade of malignancy and relative PME peak area. An overlap in spectral characteristics between the benign and malignant cases of splenomegaly existed. Serial studies in a patient with high grade lymphoma receiving combination chemotherapy showed changes in phosphorus spectra, with an increase in the phosphodiester/b̃adenosine triphosphate ratio.