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19 F MRS studies of fluoropyrimidine chemotherapy. A review
Author(s) -
McSheehy P. M. J.,
Griffiths J. R.
Publication year - 1989
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940020402
Subject(s) - chemotherapy , medicine , oncology , nuclear medicine , radiochemistry , chemistry
19 F NMR spectroscopy (MRS) has been used to follow the metabolism of the fluoropyrimidine anticancer drug 5‐fluorouracil and its derivatives non‐invasively, both in animals and humans. This review is concerned with the information that has been acquired concerning cytotoxicity and detoxification in relation to studies performed with conventional methods. The potential uses of 19 F MRS of fluoropyrimidines in research, particularly concerning combination chemotherapy, and in monitoring therapy, are discussed.